[Thèse] Complex Event Processing in an AI System for Healthcare

Niveau : Doctorat

Période : 2024-2027

Keywords:

Complex Event Processing, AI System, Healthcare Data, Digital Twin, Data Stream
Processing, Root Cause Analysis, Counterfactual Analysis.

Supervisors:

Fabien Picarougne, Guillaume Raschia, Vincent Ricordel

Context

The PhD will take place in the European THCS “Transforming Health and Care Systems”
project RENEW which means “Reshaping data-driven smart healthcare to optimize resources
and personalize care for hypertensive patients through AI and digital twin models”. The RENEW
project has started in June 2024 for 3 years long. It involves 9 partners from Romania, Suede,
Switzerland, Poland, Italy, Slovenia and France. The LS2N partner leads the work package
about the smart data processing, the personal profiles and digital twin design.

Objectives

Health and well-being at home require to monitor in near-real time a bunch of measures and
raw events at a large scale and a high frequency, coming both from the individuals and their
environment. Focusing on hypertensive patients only, it is well-known that lifestyle (diet,
physical activity, tobacco, alcohol, overweight) plays a crucial role in risk assessment.
Thus, the PhD aims at building, maintaining and analyzing digital twins for healthcare [1]. As
part of the RENEW project, the ultimate goal is to give feedback to individuals on their practices
and lifestyle based on IA models [2] and stream processing [3,4]. Also, health institutions should
be able to conduct real-time analyzes and gain insights from personal models of a large cohort
of patients. All in all, it is then necessary to develop an online architecture capable of
continuously collecting, preparing and analyzing health and care data from multiple sources.

Guidelines

The PhD line of work should consider that each patient willingly operates self-quantification with
activity tracking technologies and wearable devices [5]. The many low-to-high rate signals would
be aggregated locally and updated online using unsupervised Machine Learning [6] to draw a
sketch of a personal digital twin, still preserving privacy [7] of the individuals. Those raw models
may be continuously scanned to extract useful “patterns” such that it raises the scientific issue
of applying complex event processing on the latent space of the models.
At a larger scale, personal model and patterns of each patient would be streamed to a central
node where the all collection of digital twins is expected to consistently describe the population
of individuals with interesting properties. Hence, it provides the material to conduct online
predictive analyzes regarding the health of the population. It also allows for counterfactual
scenarios, root cause analyzes and prescriptions [8] back to each patient.

References:

[1] EROL, Tolga, MENDI, Arif Furkan, et DOĞAN, Dilara. The digital twin revolution in
healthcare. In : 2020 4th international symposium on multidisciplinary studies and innovative
technologies (ISMSIT). IEEE, 2020. p. 1-7.
[2] GOMES, Hector Murilo, READ Jesse, BIFET Albert, BARDDAL Jean-Paul, GAMA Joao.
Machine learning for streaming data: state of the art, challenges, and opportunities, SIGKDD
Explor. 21(2): 6-22 (2019).
[3] GIATRAKOS, Nikos, ALEVIZOS, Elias, ARTIKIS, Alexander, et al. Complex event
recognition in the big data era: a survey. The VLDB Journal, 2020, vol. 29, p. 313-352.
[4] ZIEHN, Ariane, GRULICH, Philipp M., ZEUCH, Steffen and MARKL, Volker. Bridging the
Gap: Complex Event Processing on Stream Processing Systems. In Proceedings of EDBT
(EDBT’24), pp 447-460 (2024).
[5] Shei RJ, Holder IG, Oumsang AS, Paris BA, Paris HL. Wearable activity trackers-advanced
technology or advanced marketing? Eur J Appl Physiol. 2022 Sep;122(9):1975-1990. doi:
10.1007/s00421-022-04951-1. Epub 2022 Apr 21. PMID: 35445837; PMCID: PMC9022022.
[6] L. Wang, X. Zhang, H. Su and J. Zhu, A Comprehensive Survey of Continual Learning:
Theory, Method and Application, in IEEE Transactions on Pattern Analysis and Machine
Intelligence, vol. 46, no. 8, pp. 5362-5383, Aug. 2024, doi: 10.1109/TPAMI.2024.3367329.
[7] Liu, B., Ding, M., Shaham, S., Rahayu, W., Farokhi, F., & Lin, Z. (2021). When machine
learning meets privacy: A survey and outlook. ACM Computing Surveys (CSUR), 54(2), 1-36.
[8] Prosperi, Mattia C. F. et al. “Causal inference and counterfactual prediction in machine
learning for actionable healthcare.” Nature Machine Intelligence 2 (2020): 369 – 375.

{fabien.picarougne, guillaume.raschia, vincent.ricordel}@univ-nantes.fr
Phone: +33 6 18 75 83 54